Biomaterial Database

Confirmation of sulfonamide residues in kidney tissue by liquid chromatography-mass spectrometry. 1994

S Porter

Analytical Chemistry Unit, Central Veterinary Laboratory, Addlestone, Surrey, UK.

The development of a method to confirm the presence of sulfonamide residues in kidney tissues at levels at or above the maximum residue limit (MRL, 100 ng g-1 total sulfonamide) using a tandem mass spectrometer [i.e., mass spectrometry-mass spectrometry (MS-MS)] interfaced to a high-performance liquid chromatography is described. Although sulfonamides can be determined using a single quadrupole mass spectrometer with pseudo-MS-MS, advantages in interfacing to a tandem mass spectrometer are demonstrated.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008460	Meat	The edible portions of any animal used for food including cattle, swine, goats/sheep, poultry, fish, shellfish, and game.	Meats
D002851	Chromatography, High Pressure Liquid	Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.	Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004350	Drug Residues	Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.	Drug Residue,Residue, Drug,Residues, Drug
D000003	Abattoirs	Places where animals are slaughtered and dressed for market.	Slaughterhouses,Slaughter House,Slaughter Houses,Abattoir,House, Slaughter,Houses, Slaughter,Slaughterhouse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012680	Sensitivity and Specificity	Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	Specificity,Sensitivity,Specificity and Sensitivity
D013058	Mass Spectrometry	An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.	Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D013411	Sulfadiazine	One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.	Sulfazin,Sulfazine,Sulphadiazine,Zinc Sulfadiazine,Sulfadiazine, Zinc
D013416	Sulfamerazine	A sulfanilamide that is used as an antibacterial agent.	Methylsulfadiazine,Mebacid,Trimetox