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A comprehensive ultrastructural examination of one cross-sectional level (middle 1/3) of the arcuate nucleus of the hypothalamus (AH) of male rats several weeks after castration or after two weeks of morphine treatment confirmed a marked increased in lamellar whorls of endoplasmic reticulum in AH neurons in each group. A comparable incidence of AH whorls was not detected in rats treated with lactose, those treated for only 1--3 days with morphine, or in those given testosterone plus morphine for 2 weeks. It is postulated that the testosterone deficiency following either castration or chronic morphine treatment stimulated the observed increase in AH whorls. A close correspondence was noted between the distribution within the AH of neurons containing whorls and those reported by others to contain luteinizing hormone releasing hormone (LH-RH). The possibility that whorls may be a marker for hypothalamic neurons which play a role in the LH-RH regulatory system warrants further consideration.
M T Price, and
J W Olney, and
T J Cicero
January 1978,
Psychoneuroendocrinology,
M T Price, and
J W Olney, and
T J Cicero
November 1980,
Brain research,
M T Price, and
J W Olney, and
T J Cicero
August 1989,
Neuroendocrinology,
M T Price, and
J W Olney, and
T J Cicero
January 1981,
Ontogenez,
M T Price, and
J W Olney, and
T J Cicero
April 1995,
Histology and histopathology,
M T Price, and
J W Olney, and
T J Cicero
March 1978,
Pharmacology, biochemistry, and behavior,
M T Price, and
J W Olney, and
T J Cicero
January 1975,
Verhandlungen der Anatomischen Gesellschaft,
M T Price, and
J W Olney, and
T J Cicero
January 1982,
Roczniki Akademii Medycznej im. Juliana Marchlewskiego w Bialymstoku,
M T Price, and
J W Olney, and
T J Cicero
January 1965,
Science (New York, N.Y.),
M T Price, and
J W Olney, and
T J Cicero
January 1965,
Science (New York, N.Y.),
