Biomaterial Database

How do colorectal cancers develop? 1995

S Kuramoto, and T Oohara

Third Department of Surgery, University of Tokyo, Japan.

BACKGROUND The aim of this study was to reveal (1) whether a flat adenoma is the precursor of a flat cancer and (2) the more frequent pathway in colorectal cancer development-a flat cancer or a polypoid cancer. METHODS Clinical features and histologic characteristics of 97 flat early cancers, 138 polypoid early cancers, 60 advanced cancers involving the muscularis propria, and 185 flat adenomas were investigated. RESULTS Of the flat cancers, 89.7% were not accompanied by residual adenoma and are considered to have arisen de novo. The distribution of flat adenomas and flat cancers was significantly different, and a follow-up of flat adenomas did not reveal any rapid growth or carcinomatous changes in the flat adenomas. The shape of advanced cancers involving only the muscularis propria almost matches that of flat early cancers. Fifty-two of 97 flat cancers and 19 of 138 polypoid cancers invaded the submucosal layer. CONCLUSIONS Flat adenomas are not considered to be precursors of flat cancers. Advanced cancers of the large intestine originate mainly from flat cancers arising de novo. The percentage of the advanced cancers that originate from flat cancers is estimated to be 71.2% (52 of 52 +/- 19) at a minimum.

UI	MeSH Term	Description	Entries
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236	Adenoma	A benign epithelial tumor with a glandular organization.	Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D015179	Colorectal Neoplasms	Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	Colorectal Cancer,Colorectal Carcinoma,Colorectal Tumors,Neoplasms, Colorectal,Cancer, Colorectal,Cancers, Colorectal,Carcinoma, Colorectal,Carcinomas, Colorectal,Colorectal Cancers,Colorectal Carcinomas,Colorectal Neoplasm,Colorectal Tumor,Neoplasm, Colorectal,Tumor, Colorectal,Tumors, Colorectal
D018450	Disease Progression	The worsening and general progression of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.	Clinical Course,Clinical Progression,Disease Exacerbation,Exacerbation, Disease,Progression, Clinical,Progression, Disease