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In two patients with terminal renal failure the night-day rhythm of plasma aldosterone (PA) renin activity (PRA) and plasma cortisol (PC) were examined before and after bilateral nephrectomy and after renal transplantation. Before nephrectomy changes in abnormally high PA coincided with PC whereas no significant correlation was observed between PA and PRA. In the anephric state secretory episodes of PA occurred independent from those of PC while PRA was undetectable. After renal transplantation a lack of night-day variation in renin secretion was observed in both patients; only one of the two patients showed episodic secretion of PA while PC was suppressed in both patients probably due to the chronic administration of prednisone. Our results indicate, that before nephrectomy under the conditions described in this study plasma aldosterone was predominantly controlled by ACTH. In the anephric state and after renal transplantation other (yet unidentified) factors might have caused episodic secretion of aldosterone. Finally, the lack of night-day variation and secretory episodes in renin secretion after transplantation points to an important role of the sympathetic nervous system in the control of circadian and episodic renal renin release.
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
January 1973,
Annals of internal medicine,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
May 1975,
Kidney international,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
January 1974,
Transactions - American Society for Artificial Internal Organs,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
April 1977,
Sbornik lekarsky,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
January 1974,
Kidney international,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
July 1976,
Deutsche medizinische Wochenschrift (1946),
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
February 1982,
The American journal of physiology,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
April 1978,
Nihon Jinzo Gakkai shi,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
January 1980,
International urology and nephrology,
W Vetter, and
K Záruba, and
H Armbruster, and
R Beckerhoff, and
G Uhlschmid, and
J Furrer, and
W Siegenthaler
September 1975,
Kidney international. Supplement,
