Biomaterial Database

Topical gentamicin vestibular toxicity. 1994

N S Longridge

Division of Otolaryngology, University of British Columbia, Faculty of Medicine, Vancouver General Hospital.

Two patients with large tympanic membrane perforations received Garasone eardrops. They developed severe acute vestibular deafferentation. In one patient, the middle ear mucosa was healthy and uninfected, and in the other ear, it was inflamed. It is recommended that caution be used in administration of Garasone to the middle ear. If damage can occur with gentamicin, it likely occurs with other ototoxic agents. It is recommended that ototoxic agents not be used in uninflamed middle ears during surgery. The patient should be instructed to treat the discharge through a perforation or tube for only 2 days after the discharge from the external canal ceases.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D005839	Gentamicins	A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	Gentamicin Sulfate (USP),Gentamycin,G-Myticin,Garamycin,Gentacycol,Gentamicin,Gentamicin Sulfate,Gentamycins,Gentavet,Genticin,G Myticin,GMyticin,Sulfate, Gentamicin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287	Administration, Topical	The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.	Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D015837	Vestibular Diseases	Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.	Disease, Vestibular,Diseases, Vestibular,Vestibular Disease
D018058	Tympanic Membrane Perforation	A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.	Eardrum Perforation,Tympanic Membrane Rupture,Membrane Perforation, Tympanic,Membrane Rupture, Tympanic,Perforation, Eardrum,Rupture, Tympanic Membrane