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Midline granuloma (MG), limited Wegener's granulomatosis (LWG), and generalized Wegener's granulomatosis (WG) have been viewed by some investigators as representing an interrelated disease spectrum. Others believe that MG and WG are two distinct clinicopathologic entities. A series of cases is presented suggesting that therapy of MG should be individualized. Treatment may include corticosteroids, high-dose irradiation, and/or immunosuppressive drugs. LWG may be treated initially with corticosteroids alone, but lack of response requires the addition of an immunosuppressive agent. WG should be treated with an immunosuppressive drug and, at times, corticosteroids as well. None of the cases of MG described in this report progressed to WG. This may be interpreted as supporting the contention that MG and WG are separate diseases. Alternatively, aggressive treatment of MG with irradiation or immunosuppressives may prevent its transition to more generalized disease.
S L Schechter, and
G G Bole, and
S E Walker
January 1992,
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale,
S L Schechter, and
G G Bole, and
S E Walker
January 1961,
Oncologia,
S L Schechter, and
G G Bole, and
S E Walker
January 1994,
Ryoikibetsu shokogun shirizu,
S L Schechter, and
G G Bole, and
S E Walker
February 1968,
The Journal of laryngology and otology,
S L Schechter, and
G G Bole, and
S E Walker
January 1979,
Head & neck surgery,
S L Schechter, and
G G Bole, and
S E Walker
July 1984,
Zhonghua nei ke za zhi,
S L Schechter, and
G G Bole, and
S E Walker
May 1976,
Annals of internal medicine,
S L Schechter, and
G G Bole, and
S E Walker
June 1969,
Arthritis and rheumatism,
S L Schechter, and
G G Bole, and
S E Walker
January 1992,
Rhinology. Supplement,
S L Schechter, and
G G Bole, and
S E Walker
December 1959,
A.M.A. archives of otolaryngology,
