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HLA haplotype distribution was analyzed in nuclear families of patients with insulin-dependent diabetes mellitus. Sixteen families with two or more diabetic siblings were examined, a total of 69 subjects, 33 of these diabetic siblings and 36 normal subjects (siblings and parents). The data were processed using the involved sibling pairs method based on a mixed model making use of a conditional probability approach. The ratio of diabetic sibling pairs concordant by 2 haplotypes, 1 haplotype, and discordant by 2 haplotypes was 9:5:2 vs. 1:2:1 expected according to Mendel's accidental distribution (p < 0.025). Increased incidence of siblings concordant by 2 haplotypes proves the presence in the HLA domain of one or several genes responsible for the development of diabetes mellitus. Siblings identical by two HLA haplotypes with the diabetic proband are at a higher risk of developing this disease.
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
August 1984,
American journal of epidemiology,
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
November 1999,
Journal of endocrinological investigation,
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
January 1997,
Journal of the peripheral nervous system : JPNS,
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
March 1991,
Nursing standard (Royal College of Nursing (Great Britain) : 1987),
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
December 1989,
European journal of epidemiology,
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
October 1987,
British medical journal (Clinical research ed.),
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
December 1987,
British medical journal (Clinical research ed.),
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
January 1989,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
October 1981,
Lancet (London, England),
I P Domuschiev, and
T L Kuraeva, and
A S Sergeev, and
V V Iazdovskiĭ, and
L N Denisov, and
V P Maksimova, and
O M Smirnova, and
G A Romanovskaia
February 1991,
Clinical and investigative medicine. Medecine clinique et experimentale,
