Previous studies have indicated that the skin bleeding time test does not accurately reflect visceral bleeding time (BT). The present study examines the predictive value of the skin bleeding time for brain bleeding tendency. Sixteen Sprague-Dawley rats were divided into equal groups. The first group (controls) underwent standardized skin and brain bleeding time tests under general anesthesia. Mean skin BT was found to be 168.8 sec with a standard deviation of +/- 20.8 sec. Mean brain BT was found to be 172.5 sec with a standard deviation of +/- 19.6 sec. The second group was given 23.2 mg/kg of aspirin per day for five days prior to skin and brain BT testing. Mean skin BT in this group was 315 seconds with a standard deviation of +/- 72.2 sec which proved to be significantly different from the control skin BT (P = 0.0005). Brain BT in the aspirin treated group was 155.6 sec with a standard deviation of +/- 22.6 sec. Brain BT in both control and aspirin treated groups was not significantly different (P = 0.13). All animals were euthanized 30 minutes after brain BT and their brains harvested. One animal in the control group showed evidence of a small subcortical hemorrhage upon brain sectioning. Sectioned brains in the aspirin-treated group showed no evidence of subcortical hematoma. The results indicate that skin BT is prolonged by aspirin administration, but brain bleeding time is unaffected. Brain hemostasis is likely more dependent on intrinsic procoagulant than platelet function. The skin BT test may therefore be of little utility as a preoperative screening test for neurosurgical patients.