Biomaterial Database

[Differences in susceptibility to peripheral infection with Japanese encephalitis virus among inbred strains of mouse]. 1994

S Matsuo, and K Morita, and K Bundo-Morita, and A Igarashi

Animal Research Center, Nagasaki University.

We compared susceptibility of inbred mouse strains against intracerebral as well as peripheral challenge of a flavivirus, Japanese encephalitis (JE) virus, and the results were summarized as follows: (1) Seven inbred mouse strains (C3H/He, C57BL/6, BALB/c, AKR/N, NC, NZB, DBA/2) could be classified into following 3 groups by their mortality and infection rate when they were subcutaneously challenged with a wild JE virus strain isolated from field-caught mosquitoes at a single passage in mouse (B18AM, B-1): (1) high mortality and high infection rate (C3H/He, C57BL/6, AKR/N), (2) low mortality but high infection rate (BALB/c, NC, NZB), and (3) low mortality and low infection rate (DBA/2). The DBA/2 strain showed lowest mortality and infection rate with statistically significant difference with other strains. (2) Three inbred mouse strains (C3H/He, C57BL/6, BALB/c) were peripherally challenged with following 6 different wild strains of JE virus: mosquito origin after a single passage in mouse (B-1); mosquito origin after 30 passages in mice by subcutaneous inoculations (BP-30), mosquito origin after 30 passages in mice by intracerebral inoculations (BB-30); human origin after a single passage in mouse (JaNH180,J-1); human origin after 30 passages in mice by subcutaneous inoculations (JP-30); human origin after 30 passages in mice by intracerebral inoculations (JB-30). Survival of these inbred mice showed curves, with statistical difference among mouse strains. Anti-JE ELISA antibody titers in survived mice were lowest in BALB/c among 3 inbred mouse strains for all JE virus strains used to the challenge experiment. The result indicated that BALB/c would be a suitable host to study inapparent JE virus infection which is frequent among humans exposed to JE virus. (3) Male mice showed higher mortality than females when 4 weeks old mice were peripherally challenged by JE virus, and the difference was statistically significant. The results as a whole indicated that the susceptibility of mice to JE virus is under the control of genetic factors.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D004664	Encephalitis Virus, Japanese	A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.	Japanese B Encephalitis Virus,Japanese Encephalitis Virus,Virus, Japanese Encephalitis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012737	Sex Factors	Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.	Factor, Sex,Factors, Sex,Sex Factor
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D020022	Genetic Predisposition to Disease	A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.	Genetic Predisposition,Genetic Susceptibility,Predisposition, Genetic,Susceptibility, Genetic,Genetic Predispositions,Genetic Susceptibilities,Predispositions, Genetic,Susceptibilities, Genetic