Biomaterial Database

[The normal fibrinolytic activity of the oral mucosa and saliva and in pathology]. 1994

S I Zhad'ko

Local fibrinolysis was studied of oral cavity in healthy individuals (n = 20) and in patients suffering from inflammatory changes in the mucous membrane of the oral cavity (n = 23). Comparison of the results was done with reference to the indicators of the systemic fibrinolysis activity in the same persons. There has been revealed a definite fibrinolytic activity of saliva, particularly its mucinous component. In healthy subjects it is significantly higher as compared to the patients. The local fibrinolysis is provided by the activator of plasminogen rather than the enzyme plasmin. The mucous membrane of the oral cavity does not possess physiologically significant activity since the tissue activator of plasminogen it contains is extracted with 2M solution of potassium thiocyanate only. No shifts of systemic fibrinolytic potential have been revealed in inflammatory changes of the mucous membrane.

UI	MeSH Term	Description	Entries
D009061	Mouth Mucosa	Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.	Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D010960	Plasminogen Activators	A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation.	Extrinsic Plasminogen Activators,Plasminogen Activator,Uterine-Tissue Plasminogen Activator,Uterine Tissue Plasminogen Activator
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003778	Dentures	An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.	Denture
D005341	Fibrinolysin	A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.	Plasmin,Fibrogammin,Glu-Plasmin,Protease F,Thrombolysin,Glu Plasmin
D005342	Fibrinolysis	The natural enzymatic dissolution of FIBRIN.	Fibrinolyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012463	Saliva	The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.	Salivas
D013282	Stomatitis, Denture	Inflammation of the mouth due to denture irritation.	Denture Stomatitides,Denture Stomatitis,Stomatitides, Denture