The aim of this work is to show the way and means of therapy with lithium salts in psychiatry. It takes under concideration the mechanism of acting, absorbtion and distribution in human organism of these lithium salts. The practical instruction wasn't omitted. One referred the other use of lithium salts. One described the conjunction and synergy lithium with other drugs. One stretched the side effects and comlpication which can appeared in the treatment of lithium which have to be ware the doctors practitioners.