-transparent.png){kind=logo}
Black alpha-thalassemia-1: partial characterization of an approximately 80 kb deletion which includes the zeta- and alpha-globin genes. 1993
Department of Biochemistry and Molecular Biology Medical College of Georgia, Augusta 30912-2100.
A large novel alpha-thalassemia-1 deletion which includes the zeta-, alpha 2-, alpha 1-, and theta 1-globin genes is described in a Black family living in Georgia and Florida. The deletion which was characterized by restriction enzyme analysis, extends 15 to 35 kb 5' and at least 35 kb 3' to the Cap site of the zeta-globin gene. Mental retardation was not observed. The deletion was present in a 35-year-old male with Hb H disease and his mother; the major hemoglobin type in the propositus was Hb G-Philadelphia or alpha (2)68(E12)Asn-->Lys beta 2 because his second chromosome carried the -alpha G(-3.7 kb) alpha-thalassemia-2 deletion.
Related Publications
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
May 1984,
Blood,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
October 1986,
Blood,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
January 1986,
The New England journal of medicine,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
August 1997,
Blood,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
January 1988,
Hemoglobin,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
July 1990,
Blood,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
January 1982,
Hemoglobin,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
January 1989,
Progress in clinical and biological research,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
January 2002,
Acta haematologica,
T H Huisman, and
L H Gu, and
J C Liu, and
Y J Fei, and
E L Walker
November 1980,
Nucleic acids research,
