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We have studied ciliary beat frequency (CBF) of rabbit cultured tracheal epithelium by a photoelectric method in-vitro. Addition of erythromycin and roxithromycin increased CBF in a dose-dependent fashion, whereas clarithromycin was without effect. The rank order potency of macrolide was roxithromycin > erythromycin >> clarithromycin. The roxithromycin-induced increase in CBF was not altered by propranolol, AA-861, or verapamil, but partially attenuated by indomethacin. Roxithromycin increased intracellular cAMP concentrations. These results suggest that certain macrolides can stimulate airway ciliary motility probably via prostaglandin- and cAMP-dependent regulatory pathways, which may affect mucociliary transport function in the respiratory tract.
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
July 1996,
The Journal of antimicrobial chemotherapy,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
April 1990,
Acta physiologica Scandinavica,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
March 1997,
The Japanese journal of antibiotics,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
February 1991,
The American journal of physiology,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
January 1982,
Experimental eye research,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
June 1996,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
March 1997,
The Japanese journal of antibiotics,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
July 1992,
Current eye research,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
January 1982,
Progress in clinical and biological research,
K Takeyama, and
J Tamaoki, and
A Chiyotani, and
E Tagaya, and
K Konno
January 1989,
Life sciences,
