-transparent.png){kind=logo}
8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide (1, SC-19220) has been previously reported by us and others to be a PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activities. Analogs of SC-19220, in which the acetyl moiety has been replaced with pyridylpropionyl groups and their homologs, have been synthesized as illustrated by compounds 13 and 29. These and other members of this series have been shown to be efficacious analgesics and PGE2 antagonists of the EP1 subtype. This report discusses the structure activity relationships within this series.
Related Publications
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
November 1970,
Experientia,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
January 1996,
Bioorganic & medicinal chemistry,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
July 1995,
Bioorganic & medicinal chemistry,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
November 1964,
Journal of medicinal chemistry,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
March 1975,
Journal of medicinal chemistry,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
April 2010,
Bioorganic & medicinal chemistry letters,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
February 2002,
Bioorganic & medicinal chemistry letters,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
October 1983,
Life sciences,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
June 2014,
Bioorganic & medicinal chemistry,
E A Hallinan, and
T J Hagen, and
R K Husa, and
S Tsymbalov, and
S N Rao, and
J P vanHoeck, and
M F Rafferty, and
A Stapelfeld, and
M A Savage, and
M Reichman
February 2012,
Pharmacology & therapeutics,
