-transparent.png){kind=logo}
Apomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of apomorphine (5 or 10 micrograms/kg), or placebo. The difference in rCBF, before and after drug (apomorphine versus placebo), was used to identify brain areas affected by apomorphine. Compared to placebo, both doses of apomorphine increased blood flow in the anterior cingulate cortex. Apomorphine 10 micrograms/kg also increased prefrontal rCBF (right > left). No decreases in rCBF were noted following either dose of apomorphine. Apomorphine-induced increases of anterior cingulate blood flow might serve as an in vivo index of central dopamine function. Such an approach would complement established neuroendocrine challenge paradigms for investigating central dopamine neurotransmission in psychiatric illness.
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
January 1988,
Gerontology,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
January 1989,
The Journal of neuropsychiatry and clinical neurosciences,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
February 1991,
Stroke,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
March 2008,
Anesthesia and analgesia,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
January 1984,
Progress in neuro-psychopharmacology & biological psychiatry,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
November 1990,
Acta anaesthesiologica Scandinavica,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
January 1987,
European neurology,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
March 1980,
Brain research,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
January 1989,
Acta neurochirurgica,
P M Grasby, and
K J Friston, and
C J Bench, and
P J Cowen, and
C D Frith, and
P F Liddle, and
R S Frackowiak, and
R J Dolan
August 2017,
Annals of nuclear medicine,
