BIOMAT Database Logo BIOMAT Database Logo

Angiopeptin enhances acetylcholine-induced relaxation and inhibits intimal hyperplasia after vascular injury. 1993

J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112.

The effects of the somatostatin analogue, angiopeptin (BIM-23014), on neoendothelial function, as evidenced by formation of prostaglandin (PG) I2 and by acetylcholine-induced relaxation (formation of endothelial-derived relaxing factor), were investigated in the rabbit aorta. A balloon catheter injury of the thoracic and abdominal aorta was induced in New Zealand White rabbits. Animals treated with angiopeptin for 2 or 4 wk were compared with untreated rabbits at 2 or 4 wk after the induction of injury, as well as to sham-operated controls. When the rabbits were killed, vascular rings were assessed for arachidonic acid-stimulated PGI2 formation, acetylcholine-induced relaxation, and the degree of intimal hyperplasia. Vascular rings from animals treated with angiopeptin exhibited enhanced acetylcholine-induced relaxation; however, angiopeptin treatment had no effect on arachidonic acid-stimulated PGI2 formation. Intimal hyperplasia in treated animals was reduced by 36%. Treatment with another somatostatin analogue, BIM-23030, did not enhance relaxation or inhibit intimal hyperplasia. These data suggest that treatment with angiopeptin may inhibit intimal hyperplasia in part by its beneficial effect on neoendothelial function.

UI MeSH Term Description Entries
D008297 Male Males
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D010456 Peptides, Cyclic Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL). Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002404 Catheterization Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions. Cannulation,Cannulations,Catheterizations
D004357 Drug Synergism The action of a drug in promoting or enhancing the effectiveness of another drug. Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D000109 Acetylcholine A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. 2-(Acetyloxy)-N,N,N-trimethylethanaminium,Acetilcolina Cusi,Acetylcholine Bromide,Acetylcholine Chloride,Acetylcholine Fluoride,Acetylcholine Hydroxide,Acetylcholine Iodide,Acetylcholine L-Tartrate,Acetylcholine Perchlorate,Acetylcholine Picrate,Acetylcholine Picrate (1:1),Acetylcholine Sulfate (1:1),Bromoacetylcholine,Chloroacetylcholine,Miochol,Acetylcholine L Tartrate,Bromide, Acetylcholine,Cusi, Acetilcolina,Fluoride, Acetylcholine,Hydroxide, Acetylcholine,Iodide, Acetylcholine,L-Tartrate, Acetylcholine,Perchlorate, Acetylcholine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001011 Aorta The main trunk of the systemic arteries. Aortas

Related Publications

J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries.
July 1993, Circulation,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
August 2005, American journal of physiology. Regulatory, integrative and comparative physiology,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.
September 1994, Circulation,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.
June 2017, Molecular medicine (Cambridge, Mass.),
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
MicroRNA-451 inhibits vascular smooth muscle cell migration and intimal hyperplasia after vascular injury via Ywhaz/p38 MAPK pathway.
June 2019, Experimental cell research,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Local application of calcium antagonists inhibits intimal hyperplasia after arterial injury.
January 1994, Neurosurgery,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Angiopeptin induces beneficial vascular remodeling after balloon injury.
September 1997, Transplantation proceedings,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
Methyl donor diet attenuates intimal hyperplasia after vascular injury in rats.
January 2024, The Journal of nutritional biochemistry,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
C-type natriuretic peptide inhibits intimal thickening after vascular injury.
January 1995, Annals of the New York Academy of Sciences,
J T Light, and J A Bellan, and I L Chen, and L L Longenecker, and W A Murphy, and D H Coy, and P J Kadowitz, and D B McNamara
C-type natriuretic peptide inhibits intimal thickening after vascular injury.
May 1993, Biochemical and biophysical research communications,
Copied contents to your clipboard!