-transparent.png){kind=logo}
The neurophysiological effects of a novel, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester), CGP 39551, on the high pressure neurological syndrome (HPNS) were investigated in the non-human primate Papio anubis. Six animals were exposed to maximum pressures of 81 ATA in a helium and oxygen environment, on two occasions. One exposure was pretreated orally with CGP 39551 100 mg/kg 24 h before compression, the other pretreated with an equivalent volume of vehicle, in this case water. CGP 39551 significantly ameliorated the signs of HPNS, compared with controls, at pressures above 31 ATA and prevented the severe signs from occurring at the higher pressures. Onset pressures of the mild signs at low pressures were, however, unaffected. Among EEG changes, the pressure induced reduction in delta wave amplitude was prevented by CGP 39551, but the increase in the amplitude of the 7-9 Hz band was not. It is concluded that CGP 39551 may play an important role in the prophylactic treatment of HPNS.
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
June 1990,
European journal of pharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
July 1990,
Naunyn-Schmiedeberg's archives of pharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1991,
European journal of pharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1993,
Polish journal of pharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1992,
Polish journal of pharmacology and pharmacy,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1991,
Epilepsia,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1993,
Journal of neural transmission. Parkinson's disease and dementia section,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
January 1997,
Neuropharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
December 1994,
European journal of pharmacology,
P C Pearce, and
M J Halsey, and
C J Maclean, and
E M Ward, and
J Pearson, and
M Henley, and
B S Meldrum
March 1994,
British journal of pharmacology,
