Biomaterial Database

Use of fertility drugs in the United States, 1973 through 1991. 1993

D K Wysowski

Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Maryland.

There has been a 1.9-fold increase over nearly 20 years in the number of dispensed prescriptions for CC. Since its marketing in 1967, CC has been the major drug prescribed for infertility. In 1973, there were an estimated 390,000 prescriptions for this drug; by 1991, 731,000. From 1984 through 1991, chorionic gonadotropin, menotropins, and urofollitropin together accounted for no more than one third of the market share of the gonadotrophin class of drugs, whose primary indication is treatment of infertility. These drugs were primarily prescribed by obstetrician gynecologists to white females, 20 to 39 years of age, for treatment of infertility of unspecified origin.

UI	MeSH Term	Description	Entries
D007246	Infertility	A reduced or absent capacity to reproduce.	Sterility,Reproductive Sterility,Sterility, Reproductive,Sub-Fertility,Subfertility
D008297	Male		Males
D008596	Menotropins	Extracts of urine from menopausal women that contain high concentrations of pituitary gonadotropins, FOLLICLE STIMULATING HORMONE and LUTEINIZING HORMONE. Menotropins are used to treat infertility. The FSH:LH ratio and degree of purity vary in different preparations.	Gonadotropins, Human Menopausal,Human Menopausal Gonadotropin,CP-89044,CP-90033,HMG Ferring,HMG Lepori,HMG Massone,Humegon,Menogon,Menopur,Menotrophin,Normegon,ORG-31338,Pergonal,Pergonal-500,CP 89044,CP 90033,CP89044,CP90033,Gonadotropin, Human Menopausal,Human Menopausal Gonadotropins,Lepori, HMG,Menopausal Gonadotropin, Human,ORG 31338,ORG31338,Pergonal 500,Pergonal500
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002996	Clomiphene	A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.	Chloramiphene,Clomifene,Clomid,Clomide,Clomifen,Clomiphene Citrate,Clomiphene Hydrochloride,Clostilbegit,Dyneric,Gravosan,Klostilbegit,Serophene,Citrate, Clomiphene,Hydrochloride, Clomiphene
D003456	Cryptorchidism	A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.	Testis, Undescended,Abdominal Cryptorchidism,Bilateral Cryptorchidism,Cryptorchidism, Unilateral Or Bilateral,Cryptorchism,Inguinal Cryptorchidism,Testes, Undescended,Undescended Testis,Unilateral Cryptorchidism,Cryptorchidism, Abdominal,Cryptorchidism, Bilateral,Cryptorchidism, Inguinal,Cryptorchidism, Unilateral,Undescended Testes
D005260	Female		Females
D005299	Fertility Agents	Drugs used to increase fertility or to treat infertility.	Infertility Agents,Fertility Drugs,Fertility Effect,Fertility Effects,Infertility Drugs,Infertility Effect,Infertility Effects,Agents, Fertility,Agents, Infertility,Drugs, Fertility,Drugs, Infertility,Effect, Fertility,Effect, Infertility,Effects, Fertility,Effects, Infertility