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The effects of various beta-adrenergic receptor antagonists on nicotine-induced tail-tremor were investigated in rats. Atenolol (5 and 10 mg/kg, IP), arotinolol (5 and 10 mg/kg, IP), and carteolol (5 and 10 mg/kg, IP), hydrophilic beta-adrenergic receptor antagonists, did not affect the tail-tremor induced by nicotine given at a dose of 0.5 mg/kg SC. However, propranolol (5-20 mg/kg, IP) and pindolol (5-20 mg/kg, IP), nonselective and lipophilic beta-adrenergic receptor antagonists, did suppress the tail-tremor dose dependently. In contrast, metoprolol (5-20 mg/kg, IP), lipophilic and beta 1-selective adrenergic receptor antagonists, did not show such an effect. These results suggest that nicotine-induced tail-tremors may be mediated through central beta 2-adrenergic receptors as an appearance and developmental mechanism.
K Suemaru, and
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Y Araki
April 1985,
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K Suemaru, and
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K Furuno, and
Y Araki
November 1971,
The Practitioner,
K Suemaru, and
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Y Araki
January 1982,
Renal physiology,
K Suemaru, and
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K Furuno, and
Y Araki
November 1984,
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K Suemaru, and
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December 1965,
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K Suemaru, and
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Y Araki
April 1994,
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K Suemaru, and
Y Gomita, and
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Y Araki
August 1981,
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K Suemaru, and
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K Furuno, and
Y Araki
May 1995,
Psychopharmacology,
K Suemaru, and
Y Gomita, and
K Furuno, and
Y Araki
October 2009,
Fukuoka igaku zasshi = Hukuoka acta medica,
K Suemaru, and
Y Gomita, and
K Furuno, and
Y Araki
August 1969,
Il Farmaco; edizione scientifica,
