Biomaterial Database

[Excretion of gamma-glutamyltranspeptidase in urine of patients treated with gentamicin]. 1993

Z Chodorowski, and J Umiastowski, and M Bielaszewski

I Kliniki Chorób Wewnetrznych i Ostrych Zatruć Instytutu Chorób Wewnetrznych Ak. Med., Gdańsku.

The excretion of gamma-glutamyltranspeptidase (GGTP) in 240 hour urine was studied in 21 patients treated with gentamicin for bronchopneumonia. The treatment was conducted for a period of 8-10 days using gentamicin in a dose of 2-5 mg/kg body weight daily. The studies of GGTP urine excretion were carried out on the first and the last day of the treatment, and on the 10th day after completion of treatment. A statistically significant increase of GGTP excretion was found during the treatment with gentamicin, as well as return of enzymuria to the initial values on the 10th day after competition of treatment. Only in three patients an increase was found of serum creatinine concentration > or = 0.5 mg% (44 mcmol/l).

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001996	Bronchopneumonia	Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.	Bronchial Pneumonia,Bronchial Pneumonias,Bronchopneumonias,Pneumonia, Bronchial,Pneumonias, Bronchial
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260	Female		Females
D005723	gamma-Glutamyltransferase	An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.	GGTP,Glutamyl Transpeptidase,gammaglutamyltransferase,gamma-Glutamyl Transpeptidase,Transpeptidase, Glutamyl,Transpeptidase, gamma-Glutamyl,gamma Glutamyl Transpeptidase,gamma Glutamyltransferase
D005839	Gentamicins	A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	Gentamicin Sulfate (USP),Gentamycin,G-Myticin,Garamycin,Gentacycol,Gentamicin,Gentamicin Sulfate,Gentamycins,Gentavet,Genticin,G Myticin,GMyticin,Sulfate, Gentamicin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly