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Studies on the susceptibility of adult BL6 nude (congenitally athymic, nu/nu) mice, their euthymic littermates (+/nu) and Swiss mice to Japanese encephalitis (JE) virus inoculated subcutaneously were carried out. The mice were observed over a period of 60 days p.i. for sickness and/or death, which was noticed only in nu/nu mice. However, the onset and the duration of sickness varied and no definite pattern was observed. Thirty four of 53 nu/nu, 28 of 42 +/nu and 30 of 52 Swiss mice bled during the first 5 days p.i. exhibited viraemia. Interestingly, only nu/nu mice had secondary viraemia during the period of sickness. The cause of sickness and death in nu/nu mice was confirmed by recovering the virus from the blood, the brain and other organs. Antibodies were detected in the sera of +/nu and Swiss mice from the 10th day p.i. onwards but not in nu/nu mice. These findings indicate the important role of functional T cells both in induction of active immunity and protection against JE virus infection in mice.
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L V Hungund
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V J Lad, and
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V J Lad, and
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Infection and immunity,
V J Lad, and
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L V Hungund
June 1981,
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V J Lad, and
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L V Hungund
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V J Lad, and
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V L Ayachit, and
J J Rodrigues, and
L V Hungund
February 1976,
Journal of the Reticuloendothelial Society,
V J Lad, and
A K Gupta, and
M K Goverdhan, and
V L Ayachit, and
J J Rodrigues, and
L V Hungund
March 1984,
Infection and immunity,
