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This study describes the application of LC/MS/MS to the determination of phase I and phase II metabolites of tamoxifen in urine and plasma samples of breast cancer patients. In the plasma extracts, in addition to the parent drug and N-desmethyltamoxifen, a minor metabolite tamoxifen N-oxide was identified for the first time in human. Four intact glucuronides of tamoxifen metabolites were isolated in the 24-hr posttreatment urine sample. They were the glucuronides of 4-hydroxytamoxifen, 4-hydroxy-N-desmethyltamoxifen, dihydroxytamoxifen, and a monohydroxy-N-desmethyltamoxifen. Hydroxylation followed by glucuronidation is a well-established metabolic route of tamoxifen, and this study describes for the first time direct analyses of these metabolites in human urine samples using on-line LC tandem MS.
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
March 1998,
Clinical cancer research : an official journal of the American Association for Cancer Research,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
October 1976,
Cancer treatment reports,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
January 1990,
Journal of cancer research and clinical oncology,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
February 1993,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
May 2001,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
January 1986,
The Journal of international medical research,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
December 2019,
BMC pharmacology & toxicology,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
February 2010,
Clinical cancer research : an official journal of the American Association for Cancer Research,
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
January 1990,
European journal of cancer (Oxford, England : 1990),
G K Poon, and
Y C Chui, and
R McCague, and
P E Lłnning, and
R Feng, and
M G Rowlands, and
M Jarman
January 2001,
Anticancer research,
