-transparent.png){kind=logo}
The efficacy of sodium nitroprusside in resolving cerebral vasospasm was evaluated with multicisternal injections. Twelve animals received fresh, unheparinized arterial blood via three injections (15 ml total) into the cisterna magna. Selective vertebral arteriography was performed on Day 0, and blood injections were performed on the second and third days after the first injection. On the seventh day selective arteriography was performed to evaluate the diameter of the basilar artery. In the sodium nitroprusside group, intrathecal injections of the drug were started on Day 4 and continued for two days (25 micrograms/kg/day). The diameter of the basilar artery was reduced 72.98 +/- 11.07% in control experiments. For the animals treated with intrathecal sodium nitroprusside, the mean diameter of the basilar artery was reduced 29.25 +/- 4.54%. The effect of intrathecal sodium nitroprusside on intracranial pressure (ICP), blood pressure (BP) and electrocardiogram (ECG) was also evaluated in 14 animals. There were no prominent changes in ICP, BP, or ECG when sodium nitroprusside was given intrathecally, but BP decreased and ICP and heart rate increased with intravenous doses of sodium nitroprusside. These results support the hypothesis that sodium nitroprusside administered intrathecally is an effective treatment for cerebral vasospasm.
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
January 2005,
Acta neurochirurgica. Supplement,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
August 2003,
British journal of neurosurgery,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
March 1984,
Zhonghua nei ke za zhi,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
July 1999,
Stroke,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
May 2002,
Neurosurgery,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
May 2000,
Stroke,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
February 1982,
Archives of internal medicine,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
April 1984,
The Annals of thoracic surgery,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
January 1964,
Bulletin de la Societe internationale de chirurgie,
N Egemen, and
R K Türker, and
U Sanlidilek, and
A Zorlutuna, and
S Bilgiç, and
M Baskaya, and
A Unlü, and
S Caglar, and
R F Spetzler, and
J M McCormick
January 1965,
The Journal of cardiovascular surgery,
