BIOMAT Database Logo BIOMAT Database Logo

Regulation of the human IgE response by IL4 and IL13. 1993

J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
DNAX Research Institute, Human Immunology Department, Palo Alto, CA 94304-1104.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D002450 Cell Communication Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP. Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D015496 CD4-Positive T-Lymphocytes A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes. T4 Cells,T4 Lymphocytes,CD4-Positive Lymphocytes,CD4 Positive T Lymphocytes,CD4-Positive Lymphocyte,CD4-Positive T-Lymphocyte,Lymphocyte, CD4-Positive,Lymphocytes, CD4-Positive,T-Lymphocyte, CD4-Positive,T-Lymphocytes, CD4-Positive,T4 Cell,T4 Lymphocyte
D015847 Interleukin-4 A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells. B-Cell Growth Factor-I,B-Cell Stimulatory Factor-1,Binetrakin,IL-4,Mast Cell Growth Factor-2,B Cell Stimulatory Factor-1,B-Cell Growth Factor-1,B-Cell Proliferating Factor,B-Cell Stimulating Factor-1,B-Cell Stimulatory Factor 1,BCGF-1,BSF-1,IL4,MCGF-2,B Cell Growth Factor 1,B Cell Growth Factor I,B Cell Proliferating Factor,B Cell Stimulating Factor 1,B Cell Stimulatory Factor 1,Interleukin 4,Mast Cell Growth Factor 2
D017578 Immunoglobulin Class Switching Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. Class Switching,Ig Class Switching,Isotype Switching,Class Switching, Ig,Class Switching, Immunoglobulin,Class Switchings,Class Switchings, Ig,Class Switchings, Immunoglobulin,Ig Class Switchings,Immunoglobulin Class Switchings,Isotype Switchings,Switching, Class,Switching, Ig Class,Switching, Immunoglobulin Class,Switching, Isotype,Switchings, Class,Switchings, Ig Class,Switchings, Immunoglobulin Class,Switchings, Isotype
D018793 Interleukin-13 A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses. IL-13,IL 13,IL13,Interleukin 13

Related Publications

J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Sex-moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels.
August 2019, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE.
February 2022, Scientific reports,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles".
July 2014, Allergy, asthma & immunology research,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD.
December 2004, Chest,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study.
March 2004, The Journal of allergy and clinical immunology,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Regulation of the human IgE antibody response.
January 1987, International reviews of immunology,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Production of IL4 by human T cells and regulation of differentiation of T-cell subsets by IL4.
October 1993, Research in immunology,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Regulation of IgE response by IgE-binding factors.
January 1983, Monographs in allergy,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Regulation of IgE response by IgE binding factors.
June 1981, Federation proceedings,
J E de Vries, and J Punnonen, and B G Cocks, and R de Waal Malefyt, and G Aversa
Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes.
February 2006, The Journal of infectious diseases,
Copied contents to your clipboard!