-transparent.png){kind=logo}
The purpose of this study was to find genetic polymorphisms that might be useful in studies of Polynesian-Caucasian racial admixture and Polynesian disease susceptibility. The allele frequencies of six T cell receptor locus RFLP were measured in 73 Caucasians and two Polynesian ethnic groups comprising 86 Maoris and 95 Samoans. The RFLP studied were (locus/enzyme/probe): C alpha/Taq1/Y14, V alpha/Taq1/Y14, C beta/BglII/Y35, C gamma/Pvu II/HGP02, V beta 7/BamHI/V beta 7.4 and V beta 8/Bam HI/V beta 8.1. Racial differences in allele frequency were present with all six RFLP (P < 0.001). The allele frequencies of the V alpha/Taq1/Y14 and the V beta 7/BamHI/7.4 RFLP were similar in the two Polynesian groups, both of which differed from the Caucasians. The 1.4 kb allele of the V alpha/Taq1/Y14 RFLP and the 8.0 kb allele of the V beta 7/BamHI/7.4 RFLP were present in low frequency in both Polynesian groups compared to the Caucasian group, consistent with a gene flow effect. These alleles may be useful in studies of Caucasian-Polynesian racial admixture.
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
August 1992,
Immunology and cell biology,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
October 1996,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
July 1990,
Gastroenterology,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
September 1992,
Journal of neuroimmunology,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
July 1992,
Human immunology,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
September 1993,
Mammalian genome : official journal of the International Mammalian Genome Society,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
August 1998,
Neurology,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
January 1994,
Autoimmunity,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
June 1993,
Acta endocrinologica,
W G Abbott, and
P L Tan, and
M A Skinner, and
J Marbrook, and
J S Peake, and
D G Woodfield, and
A Geursen
October 2020,
Proceedings of the National Academy of Sciences of the United States of America,
