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We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM.
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
January 1996,
The Journal of urology,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
February 1999,
Yonsei medical journal,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
February 2004,
Journal of neurosurgery,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
March 2002,
Infection and immunity,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
October 2008,
Journal of neurovirology,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
July 1988,
Journal of clinical immunology,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
January 1988,
Annals of the New York Academy of Sciences,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
February 1990,
Transplantation proceedings,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
February 2000,
Transplantation,
M Ramanathan, and
M Lantz, and
R D MacGregor, and
B Huey, and
S Tam, and
Y Li, and
M R Garovoy, and
C A Hunt
August 1986,
Journal of immunology (Baltimore, Md. : 1950),
