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In the airways inflammation observed in asthma, activated macrophages are present in increased numbers. Adhesion molecules are required for the cell:cell contacts between leukocytes and endothelial cells or other leukocytes, and they are induced by inflammatory stimuli. We studied the expression of two adhesion molecules (ICAM-1 and LFA-1) on alveolar macrophages recovered by bronchoalveolar lavage from 11 normal subjects and 13 asthmatic patients by using immunocytochemistry. Two specific monoclonal antibodies were used, and the reaction was revealed by the alkaline phosphatase-antialkaline phosphatase (APAAP) method. The percentage of cells expressing ICAM-1 or LFA-1 was significantly increased in asthmatic patients, as compared with normal subjects (P < 0.001 and P < 0.002, respectively; Mann-Whitney U test), and there was a significant correlation with the percentage of cells expressing both markers in asthma (P < 0.03, Spearman rank test). This study highlights the importance of macrophages in the inflammation of asthma and suggests that macrophage interactions with other cells play a role in this inflammation.
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
April 1998,
Biochimica et biophysica acta,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
October 1991,
Chest,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
January 1995,
Annales pharmaceutiques francaises,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
February 1994,
The European respiratory journal,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
September 1993,
Biochimica et biophysica acta,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
February 1992,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
March 2001,
Medical and pediatric oncology,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
January 1995,
Journal of clinical & laboratory immunology,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
May 1994,
Annals of the New York Academy of Sciences,
P Chanez, and
A M Vignola, and
P Lacoste, and
F B Michel, and
P Godard, and
J Bousquet
January 1992,
Hematological oncology,
