-transparent.png){kind=logo}
In rats bearing a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, stimulation of adenosine A2 receptors by CGS 21680 reduced the contralateral turning behavior induced by L-3,4-dihydroxyphenylalanine (L-DOPA). Administration of CGS 21680 completely blocked the contralateral turning induced by the dopamine D1 receptor agonist, SKF 38393, and reduced the turning induced by the dopamine D2 receptor agonist, LY 171555. Quinolinic acid lesion of the striatum or 6-hydroxydopamine lesion of the dopaminergic nigro-striatal neurons demonstrated that [3H]CGS 21680 binding sites are associated to striatal intrinsic neurons. This study provides evidence for a negative postsynaptic interaction of both dopamine D1 and D2 receptors with adenosine A2 receptors.
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
May 1988,
Neuroscience letters,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
November 2003,
Synapse (New York, N.Y.),
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
July 1995,
Neuroscience,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
July 2003,
Journal of neural transmission (Vienna, Austria : 1996),
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
February 1992,
Brain research,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
March 2005,
The Journal of pharmacology and experimental therapeutics,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
October 2014,
Scientific reports,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
March 1999,
Neuroscience,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
February 1998,
Behavioural pharmacology,
M Morelli, and
S Fenu, and
A Pinna, and
G Di Chiara
August 1992,
Brain research,
