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Leukocyte adhesion deficiency was diagnosed in 4 Holstein calves from 1 to 4 months old. Calves had severe ulcers on oral mucous membranes, gingivitis, severe periodontitis, chronic pneumonia, and stunted growth associated with severe neutrophilia. Neutrophils from affected calves had function defect, characterized by severely decreased adherence, chemotactic movements, phagocytosis, luminol-dependent chemiluminescent response, and O(2-)-producing activities. Deficient CD18 expression (0.1 to 1.7%) on neutrophils was clearly detected by use of flow cytometric analysis. These affected calves were linked to a common ancestral sire that has been documented to be a carrier. Clinical features, leukocyte functional abnormalities, deficient expression of CD18, and mode of inheritance indicated that affected calves had leukocyte adhesion deficiency. In vitro leukocyte functional abnormalities were associated with deficiency in the expression of CD11/CD18. Pathologic findings indicated possible increased susceptibility to infection associated with this disease.
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
December 1997,
The Journal of veterinary medical science,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
February 1994,
DTW. Deutsche tierarztliche Wochenschrift,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
April 1994,
The Canadian veterinary journal = La revue veterinaire canadienne,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
April 1992,
The Cornell veterinarian,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
October 1993,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
March 1994,
The veterinary quarterly,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
January 1993,
Acta veterinaria Scandinavica,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
June 1992,
The American journal of pathology,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
August 1994,
American journal of veterinary research,
H Nagahata, and
M E Kehrli, and
H Murata, and
H Okada, and
H Noda, and
G J Kociba
October 1995,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
