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It was the aim of this study to test for a possible effect of the new non ergot dopamine agonist CV 205-502 on plasma growth hormone (GH) concentrations in acromegaly. 10 acromegalic patients received a single oral dose of 150 micrograms CV 205-502 after an overnight fast. As a control group 7 acromegalic patients undertook the same procedure without receiving any drug. Blood samples were drawn hourly up to 7 hours thereafter for determination of GH. Plasma growth hormone concentrations decreased by 48.8 +/- 8.7%. The nadir was observed 3 hours after CV 205-502 was administered and GH concentrations remained suppressed throughout the 7 hours of the test period. In contrast GH plasma concentrations in the control group remained stable. We conclude that acute administration of CV 205-502 suppresses GH secretion in acromegalic patients and thus could serve as an alternative therapy in acromegaly.
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
January 1990,
Movement disorders : official journal of the Movement Disorder Society,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
May 1990,
Annals of internal medicine,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
March 1991,
British journal of obstetrics and gynaecology,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
May 1995,
European journal of endocrinology,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
September 1988,
Clinical endocrinology,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
April 1992,
Biochemical pharmacology,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
April 1994,
Clinical endocrinology,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
February 1988,
Brain research,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
December 1990,
The Journal of clinical endocrinology and metabolism,
T Svoboda, and
H Kotzmann, and
M Clodi, and
P Bernecker, and
G Geyer, and
A Luger
May 1990,
Clinical endocrinology,
