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The effect of histamine on the activity of noradrenergic neurons terminating in discrete regions of the diencephalon was examined in male rats. Noradrenergic neuronal activity was estimated by measuring the concentration of norepinephrine and its metabolite 3-methoxy-4-hydroxyphenylethyleneglycol [MHPG] in the medial zona incerta [MZI] and in the dorsomedial [DMN], periventricular [PeVN] and medial preoptic hypothalamic nuclei [MPN]. The intracerebroventricular administration of histamine effected a time-related increase in MHPG concentrations in the MZI, DMN, PeVN and MPN; these effects were blocked by the H1 antagonist mepyramine but not the H2 antagonist zolantidine. Neither mepyramine nor zolantidine affected basal MHPG concentrations in any of the brain regions examined. These results indicate that central administration of histamine increases the activity of noradrenergic neurons projecting to the diencephalon via an action at H1 but not H2 receptors.
A E Fleckenstein, and
K J Lookingland, and
K E Moore
December 1978,
European journal of pharmacology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
June 1995,
The American journal of physiology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
April 1983,
British journal of pharmacology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
January 1987,
Farmakologiia i toksikologiia,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
April 2013,
Neuroscience letters,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
January 1995,
Virchows Archiv : an international journal of pathology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
January 2021,
Molecular pain,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
April 2010,
Naunyn-Schmiedeberg's archives of pharmacology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
April 2006,
Journal of neurophysiology,
A E Fleckenstein, and
K J Lookingland, and
K E Moore
December 2012,
Brain research bulletin,
