During the 12-year period of retrospective observation, 38 cases of 93 major depressive inpatients were delusional and the remainders were nondelusional. We evaluated the differences on several variables, especially about suicide, between the two groups. The mean age at the onset of illness of delusional depressive patients was higher than that of nondelusional ones. The incidence of psychomotor retardation was lower in the former group than in the latter. The frequency of suicidal ideation and suicidal attempts were higher in the former group than the latter. The suicidal methods in the delusional depressives tended to be more active and violent than those in nondelusional depressives and were supposed to have a twofold mortality than those in the nondelusional ones. We discussed this high rate of suicides of delusional depression from the viewpoint of disinhibition of psychomotor retardation, chronicity, partial affinity of delusional depressives to schizophrenics and neuroendocrinological perspective.