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OBJECTIVE Our aim was to determine the efficacy and toxicity of paclitaxel in the treatment of refractory and platinum-resistant epithelial ovarian cancer. METHODS Eligibility required three prior failed chemotherapy regimens and documented platinum resistance. One hundred patients with advanced ovarian cancer received paclitaxel 135 mg/m2 over 24 hours every 21 days with optional granulocyte colony-stimulating factor support. RESULTS Paclitaxel was generally well tolerated. In four patients bowel perforation or fistula developed. After three cycles 34% of patients had stable disease and 25% of patients demonstrated a response, either partial or complete. After six cycles 24% of patients continued to respond. To date, six patients have achieved a complete response. CONCLUSIONS A 25% response rate in patients with refractory ovarian cancer was observed, which was durable to six cycles.
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
May 2002,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
May 1993,
The Medical letter on drugs and therapeutics,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
August 1995,
Australian and New Zealand journal of medicine,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
January 1995,
Investigational new drugs,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
October 1994,
Seminars in oncology,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
January 1994,
Annals of oncology : official journal of the European Society for Medical Oncology,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
February 1991,
British journal of cancer,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
November 2000,
Clinical cancer research : an official journal of the American Association for Cancer Research,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
October 1994,
Seminars in oncology,
V L Seewaldt, and
B E Greer, and
J M Cain, and
D C Figge, and
H K Tamimi, and
W S Brown, and
S A Miller
November 1993,
Seminars in oncology nursing,
