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Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was effective in suppressing adjuvant-induced arthritis in rats. Clinical and humoral parameters were studied during a 3-month period of drug administration followed by a 3-month period under placebo. The drug was absorbed, well tolerated, and its action was manifested by a drop in the mean IgG blood levels in the third week of treatment accompanied by clinical improvement after 5 weeks of oral gold intake. Together with IgG changes, an increase of the albumin ratio was observed, as well as a decrease of alpha2-globulin and rheumatoid factor titres. From a total number of 60 swollen joints found initially in the 8 patients only 17 were swollen at week 12 and 9 at week 15. Although the number of patients treated was too small to allow definite conclusions, a follow-up study under placebo of clinical and laboratory changes in the same patients during another 3-month period showed that IgG serum levels rapidly reverted preceding a flare up of disease activity after withdrawal of the drug. This confirmed a direct role in cause-effect relation played by the new oral gold compound.
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
December 1983,
The American journal of medicine,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
November 1982,
Casopis lekaru ceskych,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
September 1986,
The Journal of the Association of Physicians of India,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
January 1978,
The Journal of rheumatology,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
October 1986,
Ryumachi. [Rheumatism],
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
April 1987,
Annals of internal medicine,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
August 1986,
Annals of internal medicine,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
October 1986,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
August 1986,
The British journal of dermatology,
A E Finkelstein, and
D T Walz, and
V Batista, and
M Mizraji, and
F Roisman, and
A Misher
December 1984,
Clinical rheumatology,
