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OBJECTIVE To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in rheumatoid arthritis (RA). METHODS A phase I/II, open-label, dose-escalation study of 32 patients. RESULTS During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient. CONCLUSIONS Anti-ICAM-1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RA patients.
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
January 1995,
Ciba Foundation symposium,
A F Kavanaugh, and
L S Davis, and
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S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
October 2004,
Tissue antigens,
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
November 1993,
Scandinavian journal of immunology,
A F Kavanaugh, and
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L A Nichols, and
S H Norris, and
R Rothlein, and
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P E Lipsky
June 1996,
Transplantation proceedings,
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
February 2011,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
A F Kavanaugh, and
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L A Scharschmidt, and
P E Lipsky
January 2000,
Clinical and experimental rheumatology,
A F Kavanaugh, and
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L A Scharschmidt, and
P E Lipsky
October 1997,
Stroke,
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
May 1994,
Clinical immunology and immunopathology,
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
August 2002,
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA,
A F Kavanaugh, and
L S Davis, and
L A Nichols, and
S H Norris, and
R Rothlein, and
L A Scharschmidt, and
P E Lipsky
April 1996,
Japanese journal of cancer research : Gann,
