Biomaterial Database

Cerebral responses to the addition of nitrous oxide to halothane in man. 1976

T Sakabe, and T Kuramoto, and S Kumagae, and H Takeshita

Cerebral responses to the substitution of 60% nitrous oxide for nitrogen during halothane anaesthesia (0.84%, end-tidal) were studied in four patients during surgery. The mean (+/-SEM) cerebral blood flow equivalent and internal jugular venous oxygen tension during halothane anaesthesia, 17+/-3 ml blood/ml oxygen and 41+/-2 mm Hg respectively, increased significantly to 45+/-3 ml blood/ml oxygen and 54+/-3 mm Hg following the introduction of nitrous oxide. On the withdrawal of nitrous oxide, the mean cerebral blood flow equivalent and internal jugular venous oxygen tension returned gradually to the control values. Cerebral perfusion pressure and blood-gas values, other than the internal jugular venous oxygen tension, did not change significantly. Marked slowing of the e.e.g. was observed following the addition of nitrous oxide to halothane, Upon the withdrawal of nitrous oxide the e.e.g. returned to the control pattern. These results indicate that cerebral blood flow was in excess of oxygen demand during nitrous oxide/halothane anesthesia in man.

UI	MeSH Term	Description	Entries
D009609	Nitrous Oxide	Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.	Laughing Gas,Nitrogen Protoxide,Gas, Laughing,Oxide, Nitrous
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D002560	Cerebrovascular Circulation	The circulation of blood through the BLOOD VESSELS of the BRAIN.	Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004569	Electroencephalography	Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.	EEG,Electroencephalogram,Electroencephalograms
D005260	Female		Females
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor