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1 The actions of labetalol 1.0-2.0 mg/kg intravenously on blood pressure, heart rate, plasma angiotensin II and aldosterone concentrations have been studied in 20 recumbent hypertensive patients. 2 In all subjects there was a reduction in systolic and diastolic blood pressures within 5 min of completion of injection. 3 Severe hypotension was not seen but three patients who had a marked fall in blood pressure experienced side-effects. Postural hypotension was common at the end of the study. 4 Labetalol caused significant reduction in heart rate. 5 Labetalol induced significant lowering of plasma angiotensin II and in plasma aldosterone concentrations, which were most obvious when these were increased initially; overall there was a close correlation between concurrent measurements of angiotensin II and aldosterone concentrations. 6 In five patients a comparison was made against propranolol 10 mg intravenously. Labetalol was more effective in lowering blood pressure but less effective in reducing pulse rate of plasma angiotensin II concentration.
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
October 1982,
Clinical pharmacology and therapeutics,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
October 1978,
The Medical journal of Australia,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
January 1980,
Postgraduate medical journal,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
June 1982,
British journal of clinical pharmacology,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
March 1980,
British journal of clinical pharmacology,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
August 1976,
British journal of clinical pharmacology,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
June 1982,
British journal of clinical pharmacology,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
January 1981,
Arzneimittel-Forschung,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
September 1977,
The New Zealand medical journal,
P M Trust, and
E A Rosei, and
J J Brown, and
R Fraser, and
A F Lever, and
J J Morton, and
J I Robertson
July 1981,
Clinical science (London, England : 1979),
