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This study examined the antifertility effects of tamsulosin, a highly potent and a selective, alpha 1-adrenoceptor antagonist, on male rats. The drug was administered subcutaneously as a single dose (0.15 mg kg-1). The drug caused a significant reduction in fertility (measured by number of uterine implants, quantal pregnancy, and fertility index). The antifertility effect was short lived and rapid in both onset (no later than 7 h of administration) and recovery (within 7 d). Libido and mating performance remained essentially uninhibited. On the other hand, the antifertility effect was accompanied by significant impairment in ejaculatory competence and enhancement of pre-implantation losses. Based on the results of this study and our previous studies it is concluded that alpha 1-adrenoceptor blockade has a potent antifertility effect in male rats.
W D Ratnasooriya, and
R M Wadsworth
October 1995,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
W D Ratnasooriya, and
R M Wadsworth
November 1990,
Brain research bulletin,
W D Ratnasooriya, and
R M Wadsworth
January 2018,
The journal of allergy and clinical immunology. In practice,
W D Ratnasooriya, and
R M Wadsworth
June 1996,
Journal of autonomic pharmacology,
W D Ratnasooriya, and
R M Wadsworth
July 1997,
Yao xue xue bao = Acta pharmaceutica Sinica,
W D Ratnasooriya, and
R M Wadsworth
January 1997,
The Journal of pharmacology and experimental therapeutics,
W D Ratnasooriya, and
R M Wadsworth
September 1995,
British journal of urology,
W D Ratnasooriya, and
R M Wadsworth
August 1993,
British journal of pharmacology,
W D Ratnasooriya, and
R M Wadsworth
December 1981,
The Journal of allergy and clinical immunology,
W D Ratnasooriya, and
R M Wadsworth
April 1993,
European journal of pharmacology,
