BIOMAT Database Logo BIOMAT Database Logo

Expression of proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in multiple myeloma. 1994

A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Department of Pathology, Medical School, University of Athens, Greece.

We have studied 72 cases of multiple myeloma (MM) bone marrow trephine biopsies using the monoclonal antibody PC-10 and the colloid silver nitrate method for identification of proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs), respectively. PC-10 and AgNOR scores were statistically significantly different between low versus intermediate and low versus high grade of malignancy (P < 0.001), whereas their difference was not significant between intermediate and high grade. A strong correlation was identified between these two proliferation-associated indices in each histological grade. There is evidence that the proliferative state of myelomas belonging to the intermediate grade is approximately the same as that observed in high grade (blastic) ones.

UI MeSH Term Description Entries
D009101 Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. Myeloma, Plasma-Cell,Kahler Disease,Myeloma, Multiple,Myeloma-Multiple,Myelomatosis,Plasma Cell Myeloma,Cell Myeloma, Plasma,Cell Myelomas, Plasma,Disease, Kahler,Multiple Myelomas,Myeloma Multiple,Myeloma, Plasma Cell,Myeloma-Multiples,Myelomas, Multiple,Myelomas, Plasma Cell,Myelomas, Plasma-Cell,Myelomatoses,Plasma Cell Myelomas,Plasma-Cell Myeloma,Plasma-Cell Myelomas
D009687 Nuclear Proteins Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. Nucleolar Protein,Nucleolar Proteins,Nuclear Protein,Protein, Nuclear,Protein, Nucleolar,Proteins, Nuclear,Proteins, Nucleolar
D009697 Nucleolus Organizer Region The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA. Nucleolar Organizer,Nucleolar Organizers,Nucleolus Organizer Regions,Organizer Region, Nucleolus,Organizer Regions, Nucleolus,Organizer, Nucleolar,Organizers, Nucleolar,Region, Nucleolus Organizer,Regions, Nucleolus Organizer
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018809 Proliferating Cell Nuclear Antigen Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. Antigen, Proliferating Cell Nuclear,PCNA

Related Publications

A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas.
January 1995, Noshuyo byori = Brain tumor pathology,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
[Study of proliferating cell nuclear antigen (PCNA), nucleolar organizer regions (NORs) and mitotic activity in epithelial ovarian tumors].
March 1993, Nihon Sanka Fujinka Gakkai zasshi,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Nucleolar organizer regions (NORs) staining and proliferating cell nuclear antigen (PCNA) immunostaining in mucosa-associated lymphoid tissue (MALT) gastric lymphomas.
November 1993, Pathology, research and practice,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
The expression of proliferating cell nuclear antigen (PCNA) and of nucleolar organizer regions (AgNORs) correlates with the morphological type of bone marrow plasma cells in multiple myeloma (MM).
March 2003, Polskie Archiwum Medycyny Wewnetrznej,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Nucleolar organizer regions (NORs)
January 1994, Sao Paulo medical journal = Revista paulista de medicina,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors.
May 1998, International journal of molecular medicine,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Proliferating cell nuclear antigen and argyrophilic nucleolar organizer regions in patients with thymic disease.
January 1997, Oncology reports,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Nucleolar organizer regions (NORs) in adenomyosis.
January 2006, Pathology, research and practice,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
[Clinical significance of proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer region (AgNOR) in testicular tumors].
October 1995, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
A Skopelitou, and S Tselenis, and S Theocharis, and N Agnantis, and A Tsenga, and J Elemenoglou, and M Hadjiyannakis, and C Kittas
Proliferating cell nuclear antigen (PCNA) and nucleolar organiser regions in Hodgkin's disease: correlation with morphology.
May 1993, Journal of clinical pathology,
Copied contents to your clipboard!