-transparent.png){kind=logo}
The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic mobility of serum lipoproteins along with the appearance of a lipoprotein dissociation product. These effects persist during a 24 h infusion and for at least 1.5 h afterwards, and can be reproduced in vitro using purified high-density lipoprotein (HDL) or low-density lipoprotein (LDL). In control serum, Taxol binds to albumin > HDL, but after serum is exposed to Cremophor EL in vitro or in vivo substantial binding of Taxol to the lipoprotein dissociation product(s) was observed. The latter could represent an important factor in taxol biodistribution.
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
March 1994,
Journal of photochemistry and photobiology. B, Biology,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
January 1985,
Revista espanola de anestesiologia y reanimacion,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
April 1991,
Transplantation,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
January 1994,
Cancer chemotherapy and pharmacology,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
January 2003,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
August 1971,
Toxicology and applied pharmacology,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
June 1980,
British medical journal,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
January 1993,
Anticancer research,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
March 1987,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
E Sykes, and
K Woodburn, and
D Decker, and
D Kessel
January 1998,
Anticancer research,
