-transparent.png){kind=logo}
Patients with atopic dermatitis usually exhibit allergen-specific IgE antibodies against several environmental antigens. HLA restriction is presumed to be involved in the recognition of such antigens, but several previous reports have so far failed to find a significant association between atopic dermatitis and HLA antigens. In this study we examined 38 unrelated Japanese patients with severe atopic dermatitis and high serum IgE levels (greater than 800 U/ml). We investigated the serological HLA types and HLA class II alleles in this group of patients with atopic dermatitis. Frequencies of HLA-A24, A33, Cwblank, B44, DR13 and HLA-DRB1*1302, DQB1*0604, DPB1*0301 alleles were increased in the patients. In contrast, frequencies of HLA-Cw1, Bw6, DR4, DR53, and HLA-DQB1*0302 allele were decreased. However, none of these remained significant after p values were corrected. Further study on HLA association with atopic dermatitis through characterization of specific antigens or antigen epitopes is needed.
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
January 1988,
Dermatologische Monatschrift,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
January 1986,
Acta dermato-venereologica,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
May 1978,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
March 1978,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
December 1973,
Archives of dermatology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
February 2004,
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
May 2005,
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
December 2007,
International journal of dermatology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
October 1973,
The Journal of investigative dermatology,
H Saeki, and
S Kuwata, and
H Nakagawa, and
T Etoh, and
M Yanagisawa, and
M Miyamoto, and
K Tokunaga, and
T Juji, and
Y Shibata
January 1983,
Dermatologica,
