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Mg2+ in high concentration (10 to 20 mEq/l) caused a dose-related inhibition of glucose-induced 45calcium net uptake and subsequent insulin release in isolated islets. Experiments performed with the isolated perfused pancreas indicated that the inhibitory effect of Mg2+ upon insulin secretion was rapid and reversible. Although excess Mg2+ reduced lactate production by the islets, the process of glucose recognition by the B-cell was apparently unaltered as judged by the inhibitory effect of the hexose upon 45calcium efflux from perifused islets and the resultant accumulation of 45calcium in the islets. Mg2+ in high concentration failed to facilitate 45calcium efflux from the islets, whether in the presence or absence of glucose. These data suggest that the major effect of Mg2+ upon islet function is to inhibit Ca2+ entry in the B-cell.
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
August 1977,
Archives internationales de pharmacodynamie et de therapie,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
January 1977,
Hormone research,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
April 1977,
Biochemical pharmacology,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
December 1981,
Biochemical pharmacology,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
May 1981,
Biochemical pharmacology,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
October 2005,
Clinical calcium,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
March 1992,
Casopis lekaru ceskych,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
January 1983,
European journal of respiratory diseases. Supplement,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
January 1990,
Annals of the New York Academy of Sciences,
W J Malaisse, and
G Devis, and
A Herchuelz, and
A Sener, and
G Somers
September 1986,
Journal of autonomic pharmacology,
