-transparent.png){kind=logo}
We describe a 27-year-old women with systemic lupus erythematosus, C1q deficiency and cytomegalovirus retinitis. She suffered from severe SLE, with cutaneous and CNS involvement, and died of CNS disease aged 28. Review of 29 other published cases of C1q deficiency shows that SLE in these patients is often severe (five with CNS disease, ten with glomerulonephritis). The results of autoantibody studies in this and another patient with C1q deficiency and SLE are presented--both patients had autoantibodies to the extractable nuclear antigens, Sm, RNP and Ro, and one patient had high titres of antibodies to dsDNA. One of the patients had previously been treated with fresh frozen plasma, and antibodies to C1q were present in his serum. Homozygous C1q deficiency is associated with a very high prevalence of severe SLE with the full panoply of autoantibodies characteristic of this disease.
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
October 1999,
Ugeskrift for laeger,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
March 2000,
The British journal of dermatology,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
January 2016,
Frontiers in immunology,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
June 2007,
Annals of the New York Academy of Sciences,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
April 1996,
Arthritis and rheumatism,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
August 1998,
Immunobiology,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
August 1987,
The British journal of dermatology,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
November 1993,
Clinical and experimental immunology,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
January 1984,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
P Bowness, and
K A Davies, and
P J Norsworthy, and
P Athanassiou, and
J Taylor-Wiedeman, and
L K Borysiewicz, and
P A Meyer, and
M J Walport
March 1979,
Annales de dermatologie et de venereologie,
