Biomaterial Database

Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat. 1994

S Yamazaki, and M Maruyama, and F R Cagampang, and S T Inouye

Laboratory of Integrative Brain Function, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.

Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3',5'-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.

UI	MeSH Term	Description	Entries
D007032	Hypothalamus, Anterior	The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.	Hypothalamus, Supraoptic,Anterior Hypothalamic Commissure,Anterior Hypothalamic Decussation of Ganser,Anteroventral Periventricular Nucleus,Anterior Hypothalamic Commissures,Anterior Hypothalamus,Commissure, Anterior Hypothalamic,Commissures, Anterior Hypothalamic,Hypothalamic Commissure, Anterior,Hypothalamic Commissures, Anterior,Nucleus, Anteroventral Periventricular,Periventricular Nucleus, Anteroventral,Supraoptic Hypothalamus
D008297	Male		Males
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D000242	Cyclic AMP	An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.	Adenosine Cyclic 3',5'-Monophosphate,Adenosine Cyclic 3,5 Monophosphate,Adenosine Cyclic Monophosphate,Adenosine Cyclic-3',5'-Monophosphate,Cyclic AMP, (R)-Isomer,Cyclic AMP, Disodium Salt,Cyclic AMP, Monoammonium Salt,Cyclic AMP, Monopotassium Salt,Cyclic AMP, Monosodium Salt,Cyclic AMP, Sodium Salt,3',5'-Monophosphate, Adenosine Cyclic,AMP, Cyclic,Adenosine Cyclic 3',5' Monophosphate,Cyclic 3',5'-Monophosphate, Adenosine,Cyclic Monophosphate, Adenosine,Cyclic-3',5'-Monophosphate, Adenosine,Monophosphate, Adenosine Cyclic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013493	Suprachiasmatic Nucleus	An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.	Hypothalamic Suprachiasmatic Nuclei,Hypothalamic Suprachiasmatic Nucleus,Suprachiasmatic Nuclei,Suprachiasmatic Nuclei, Hypothalamic,Suprachiasmatic Nucleus, Hypothalamic
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus