Biomaterial Database

[The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinine]. 1994

P Q Chen, and G Q Li, and X B Guo

Sanya Tropical Medicine Institute, Guangzhou College of Traditional Chinese Medical.

27 patients with gametocytes of P. falciparum were divided into groups A, B and C. 1,200 mg of artemisinine was given as a daily dose for 5 days to group A, 750 mg of mefloquine plus 45 mg of primaquine as a single dose to group C. After medication, gametocyte count was observed daily in addition to the infectivity of gametocytes of P. falciparum to Anopheles dirus. In group A, the density of gametocytes and the infectivity were significantly reduced on days 4, 7, 14 and 21 during the study. In group B, the density of gametocytes was significantly reduced on days 7, 14 and 21 and the infectivity was obviously lowered on days 14 and 21 after medication. In group C, gametocytes disappeared in 5 out of 9 patients with the failure of infection to mosquitoes on day 4 after treatment. This indicates that artemisinine can effectively influence the infectivity of gametocytes of P. falciparum. Artemisinine is superior to mefloquine in blocking the transmission of P. falciparum malaria.

UI	MeSH Term	Description	Entries
D010963	Plasmodium falciparum	A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.	Plasmodium falciparums,falciparums, Plasmodium
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000852	Anopheles	A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.	Anopheles gambiae
D000962	Antimalarials	Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)	Anti-Malarial,Antimalarial,Antimalarial Agent,Antimalarial Drug,Anti-Malarials,Antimalarial Agents,Antimalarial Drugs,Agent, Antimalarial,Agents, Antimalarial,Anti Malarial,Anti Malarials,Drug, Antimalarial,Drugs, Antimalarial
D012717	Sesquiterpenes	Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24.	Farnesanes,Farnesene,Farnesenes,Sesquiterpene,Sesquiterpene Derivatives,Sesquiterpenoid,Sesquiterpenoids,Derivatives, Sesquiterpene
D015767	Mefloquine	A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.	Lariam,Mefloquine Hydrochloride,Mephloquine,Ro-21-5998-001,WR-142,490,WR-177,602,Ro 21 5998 001,Ro215998001,WR 142,490,WR 177,602,WR142,490,WR177,602
D016778	Malaria, Falciparum	Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	Plasmodium falciparum Malaria,Malaria, Plasmodium falciparum
D037621	Artemisinins	A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).