-transparent.png){kind=logo}
The 51Cr cytotoxicity test was used to measure specific antibody reactions against carcinoembryonic antigen (CEA) and isoantigen A on the surface of human colon tumor cells. When human serum or guinea pig serum was used as a source of complement, no anti-CEA or anti-isoantigen A cytotoxicity was demonstrable despite binding of specific antibodies and activation of complement at least through the C3 component on the cell surface. In contrast, specific anti-CEA and anti-isoantigen A cytotoxicity was demonstrated when rabbit serum was used as a source of complement. Specific antibody-mediated cell lysis was also achieved with guinea pig complement if the cells were treated with neuraminidase before testing. These results support the concept that certain tumor cells have surface properties that render them resistant to immune lysis.
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
March 1979,
Journal of the National Cancer Institute,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
June 1978,
Schweizerische medizinische Wochenschrift,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
July 1976,
Transplantation,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
January 1986,
Anticancer research,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
October 2005,
Clinical cancer research : an official journal of the American Association for Cancer Research,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
October 1986,
Journal of immunology (Baltimore, Md. : 1950),
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
June 1997,
Immunobiology,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
October 1975,
Journal of immunology (Baltimore, Md. : 1950),
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
July 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
W A Tompkins, and
P B Seth, and
D M Yip, and
J L Palmer, and
S R Gee, and
W E Rawls
June 1990,
Journal of surgical oncology,
