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Experimental autoimmune thyroiditis was induced in out-bred guinea pigs by isoimmunization with thyroid extract in complete Freund's adjuvant. A digestion procedure using collagenase and deoxyribonuclease was used to make viable single-cell suspensions of pooled thyroid glands from groups of animals with advanced degrees of thyroiditis. Thymus-derived or T lymphocytes, identified by their capacity to form E rosettes with rabbit erythrocytes, were found to be the predominant (75%) infiltrating lymphocyte; bone marrow-derived or B cells consitituted most of the remainder. The infiltrates of inbred animals with thyroiditis were demonstrated to contain cells capable of mediating antibody-dependent lymphoid cell-mediated cytotoxicity.
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October 1985,
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S A Paget, and
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J A van Boxel
August 1964,
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S A Paget, and
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J A van Boxel
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S A Paget, and
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Clinical and experimental immunology,
S A Paget, and
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J A van Boxel
November 1971,
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Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft,
