BIOMAT Database Logo BIOMAT Database Logo

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. 1994

M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Department of Immunobiology, Immunex Research and Development Corporation, Seattle, WA 98101-2936.

Our results indicate that interleukin (IL)-12 is an important costimulator of antigen-dependent proliferation of murine Th1 clones. In addition, we demonstrate that IL-10 inhibits splenic antigen-presenting cell (APC)-dependent proliferation of Th1 clones, at least in part, via down-regulation of APC-derived IL-12. Moreover, the failure of activated B cells to provide costimulation via IL-12 accounts for their inability to support optimal proliferative responses of Th1 clones. We also show that IL-12 regulates the ability of Th1 clones to respond to IL-4 and enhances their proliferation in response to IL-2, IL-7, or IL-15. In contrast, Th2 and Th0 clones appear refractory to the effects of IL-12, on antigen-dependent or growth factor-induced proliferation.

UI MeSH Term Description Entries
D007376 Interleukin-2 A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes. IL-2,Lymphocyte Mitogenic Factor,T-Cell Growth Factor,TCGF,IL2,Interleukin II,Interleukine 2,RU 49637,RU-49637,Ro-23-6019,Ro-236019,T-Cell Stimulating Factor,Thymocyte Stimulating Factor,Interleukin 2,Mitogenic Factor, Lymphocyte,RU49637,Ro 23 6019,Ro 236019,Ro236019,T Cell Growth Factor,T Cell Stimulating Factor
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D002999 Clone Cells A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) Clones,Cell, Clone,Cells, Clone,Clone,Clone Cell
D005260 Female Females
D006377 T-Lymphocytes, Helper-Inducer Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions. Helper Cell,Helper Cells,Helper T Cell,Helper-Inducer T-Lymphocytes,Inducer Cell,Inducer Cells,T-Cells, Helper-Inducer,T-Lymphocytes, Helper,T-Lymphocytes, Inducer,Helper T-Cells,Cell, Helper T,Cells, Helper T,Helper Inducer T Lymphocytes,Helper T Cells,Helper T-Cell,Helper T-Lymphocyte,Helper T-Lymphocytes,Helper-Inducer T-Cell,Helper-Inducer T-Cells,Helper-Inducer T-Lymphocyte,Inducer T-Lymphocyte,Inducer T-Lymphocytes,T Cell, Helper,T Cells, Helper,T Cells, Helper Inducer,T Lymphocytes, Helper,T Lymphocytes, Helper Inducer,T Lymphocytes, Inducer,T-Cell, Helper,T-Cell, Helper-Inducer,T-Cells, Helper,T-Lymphocyte, Helper,T-Lymphocyte, Helper-Inducer,T-Lymphocyte, Inducer
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000938 Antigen-Presenting Cells A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. Accessory Cells, Immunologic,Antigen-Presenting Cell,Immunologic Accessory Cells,Accessory Cell, Immunologic,Cell, Immunologic Accessory,Cells, Immunologic Accessory,Immunologic Accessory Cell,Antigen Presenting Cell,Antigen Presenting Cells,Cell, Antigen-Presenting,Cells, Antigen-Presenting
D000941 Antigens Substances that are recognized by the immune system and induce an immune reaction. Antigen

Related Publications

M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Nonclassical Antigen-Presenting Cells Stimulate the Proliferation of Th0 but not Th1/Th2 Clones and Modulate the Cytokine Pattern of T-Helper Clones.
January 1992, International archives of allergy and immunology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Interleukin-12 increases interleukin-4 production by established human Th0 and Th2-like T cell clones.
August 1995, European journal of immunology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.
September 1989, The Journal of experimental medicine,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Not only Th2 cells but also Th1 and Th0 cells express CD30 after activation.
December 1995, Journal of leukocyte biology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Rheumatoid inflammatory T-cell clones express mostly Th1 but also Th2 and mixed (Th0-like) cytokine patterns.
July 1993, Scandinavian journal of immunology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Detection of CD45iota mRNA in murine Th1 but not Th2 clones.
April 2000, Immunobiology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells.
February 1999, Journal of immunology (Baltimore, Md. : 1950),
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Intranasal bacteria induce Th1 but not Treg or Th2.
January 2009, Mucosal immunology,
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.
February 1990, Journal of immunology (Baltimore, Md. : 1950),
M K Kennedy, and K S Picha, and K D Shanebeck, and D M Anderson, and K H Grabstein
Interleukin-18 regulates both Th1 and Th2 responses.
January 2001, Annual review of immunology,
Copied contents to your clipboard!