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We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried out on the specimens. Forty-three evaluable examinations (40% of total) performed for cytopenia showed normo- or hypercellularity in 33 (77%). Fifty bone marrow specimens were cultured for mycobacteria with a yield of 42% when the indication was persistent fever. Positive cultures yielded Mycobacterium avium complex in 8 out of 12 patients. Twenty-seven patients had both culture and biopsy; granulomas were associated with all the positive (10/10) and with 1 out of 17 negative cultures (chi-square test: p < 0.001). A bone marrow involvement with lymphoma was found in 2 out of 6 patients with previously diagnosed lymphoma, and biopsy revealed a lymphoma in 2 patients. Morphological bone marrow examination should be associated with other techniques in order to appreciate bone marrow production. Bone marrow biopsy is useful for the investigation of persistent fever since granulomas suggestive of disseminated mycobacteria are frequent and allow a treatment to be initiated before microbiological confirmation and antibiotic susceptibility test.
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
July 1952,
The Journal of the Tennessee State Medical Association. Tennessee State Medical Association,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
July 2019,
Rheumatology international,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
August 2023,
International journal of laboratory hematology,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
January 1996,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
October 1996,
Revista clinica espanola,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
February 1986,
The Central African journal of medicine,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
January 1979,
The Medical journal of Australia,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
January 2023,
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India,
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
August 1996,
Anales de medicina interna (Madrid, Spain : 1984),
M Ciaudo, and
T Doco-Lecompte, and
C Guettier, and
M F d'Agay, and
F David, and
N Rioual, and
A Buu-Hoi, and
J M Molina, and
M Kazatchkine, and
J Modai
January 2006,
Gaceta medica de Mexico,
