Biomaterial Database

Behavioral effects of an antiandrogen in adult male rhesus macaques (Macaca mulatta). 1994

B L Deputte, and J Johnson, and M Hempel, and G Scheffler

Wisconsin Regional Primate Research Center, University of Wisconsin at Madison 53715-1299.

This study was designed to determine how to suppress behavioral effects of androgens with a pure non-steroidal antiandrogen, Hydroxyflutamide (OHF). The major dependent variable was yawning behavior of castrated adult male rhesus macaques. Injections of testosterone propionate (TP) increased yawning frequency and cessation of TP injections produced a decrease in yawning frequency. A similar decrease was observed with simultaneous injections of TP and OHF. It has been found that the dose of OHF injected subcutaneously should be 80 times that of TP to block the effects of either physiological or supraphysiological doses of TP.

UI	MeSH Term	Description	Entries
D008253	Macaca mulatta	A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.	Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008297	Male		Males
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females
D005485	Flutamide	An antiandrogen with about the same potency as cyproterone in rodent and canine species.	Niftolid,Apimid,Apo-Flutamide,Chimax,Cytamid,Drogenil,Euflex,Eulexin,Eulexine,Fluken,Flulem,Flumid,Fluta 1A Pharma,Fluta-GRY,Fluta-cell,Flutamin,Flutandrona,Flutaplex,Flutexin,Fugerel,Grisetin,Niftolide,Novo-Flutamide,Oncosal,PMS-Flutamide,Prostacur,Prostica,Prostogenat,SCH-13521,Testotard,Apo Flutamide,ApoFlutamide,Fluta GRY,Fluta cell,FlutaGRY,Flutacell,Novo Flutamide,NovoFlutamide,PMS Flutamide,SCH 13521,SCH13521
D000726	Androgen Antagonists	Compounds which inhibit or antagonize the biosynthesis or actions of androgens.	Androgen Antagonist,Antiandrogen,Antiandrogens,Anti-Androgen Effect,Anti-Androgen Effects,Antiandrogen Effect,Antiandrogen Effects,Antagonist, Androgen,Antagonists, Androgen,Anti Androgen Effect,Anti Androgen Effects,Effect, Anti-Androgen,Effect, Antiandrogen,Effects, Anti-Androgen,Effects, Antiandrogen
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001143	Arousal	Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.	Vigilance, Cortical,Arousals,Cortical Vigilance
D012726	Sexual Behavior, Animal	Sexual activities of animals.	Mating Behavior, Animal,Sex Behavior, Animal,Animal Mating Behavior,Animal Mating Behaviors,Animal Sex Behavior,Animal Sex Behaviors,Animal Sexual Behavior,Animal Sexual Behaviors,Mating Behaviors, Animal,Sex Behaviors, Animal,Sexual Behaviors, Animal
D012931	Social Environment	The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.	Social Context,Environment, Social,Social Ecology,Context, Social,Contexts, Social,Ecologies, Social,Ecology, Social,Environments, Social,Social Contexts,Social Ecologies,Social Environments